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Conclusion: Findings provide preliminary evidence that reduced connectivity between the TPJ and IP regions may be important for understanding mechanisms involved in persecutory ideation in patients with schizophrenia.

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Molecular and Cellular Pediatrics. 2017.

Tobacco Use Disorder is a condition characterized by the harmful consequences of repeated tobacco use, a pattern of compulsive tobacco use, and (sometimes) physiological dependence on tobacco (i.

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Drug reaction with eosinophilia and systemic symptoms (DRESS): a clinical update and review of current thinking".

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Incident diagnostic outcomes were defined as the first occurrence of either a SIPS-defined psychosis or a structured interview diagnosis from one of three non-psychotic DSM-IV groups (bipolar, non-bipolar depression, anxiety), when no diagnosis in that group was present at baseline.

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Methods: Two cellular subpopulations were isolated from postmortem DLPFC using laser capture microdissection (LCM).

Because the substantia nigra (SN) receives Glu projections from cortical areas, increased cortical Glu transmission could affect SN dopamine (DA) transmission.

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However much of this disability can be prevented if individuals with schizophrenia stay on their antipsychotic medication.

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But, Dansinger added, the study participants may not be typical of the general population.

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Children with DMDD do not go on to develop bipolar disorder, but they are at increased risk for later developing major depression or anxiety disorders.

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Background: Intrinsic functional brain networks derived from resting state functional MRI studies are viewed as promising constructs in studies of genetic underpinnings of schizophrenia (Meda et al.

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Background: Deficits in visual processing in lateral occipital visual cortex (area LO) are known to correlate with poor functional outcome in schizophrenia, but the underlying physiology of this deficit is unknown (1).

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We calculated hazard ratios for all-cause and cause-specific mortality.

Methods: We examined vitamin D levels at first onset of psychosis and in the same people 12 months later.

Evidence-based guidelines are only as current as the evidence that supports them.

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Results: Therapeutic hypotheses were not supported.

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Kate Walters, directora del Centro de Estudios sobre el Envejecimiento y la Poblacin del Colegio Universitario de Londres.

We will present average time of publication from the origination of the trial and whether the data were made available for the use by other investigators after the trial completion.

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The disorder can be difficult to diagnose at first, as the symptoms may be misidentified as features of another condition or problem.

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Sexual dysfunction and plasma prolactin levels in neuroleptic-treated schizophrenic outpatients.

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Collectively, dropout rates are lower for second- than first-generation antipsychotic drugs and appear to be partly explained by trial design features thus providing direction for future trial design.

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Psychiatry, The Mount Sinai School of Medicine, New York, NY, USA; 13.

Any work group member or reviewer who has a potential conflict of interest that may bias (or appear to bias) his or her work is asked to disclose this to the Steering Committee on Practice Guidelines and the work group.

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The real risk for suicide in mental disorders.

It has all the other nasty effects that atypical antipsychotics do like weight gain, diabetes, tardive dyskinesia and the like.

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An association with transition to psychotic disorder was tested by ANOVA including age, BMI and gender as covariates.

Using a conventional Theory of Mind (False Belief) task and a laboratory-based interactive measure of social reasoning or mentalizing ability, we investigated whether gender exerts a moderating influence on social perspective-taking in schizophrenia.

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In unipolar disorder the evidence of efficacy is less robust.

Disability and Rehabilitation, 2522, 1265.

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Methods: PRS subjects were recruited using 2 step methods, screened using Prodromal Questionnaire-Brief version (PQ-B) and interviewed with Structured Interview for Prodromal symptoms (SIPS).

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Results: Although all SEMs had excellent fit statistics, a two-factor model in which functional capacity mediates the relationship between cognition and outcome was the most parsimonious and thus chosen as the model that best fit to the data.

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Is Patient Currently Receiving Clinically Effective Medications for Bipolar Depression?

Volavka J, Czobor P, Sheitman B, Lindenmayer J-P, Citrome L, McEvoy JP, Cooper TB, Chakos M, Lieberman JA: Clozapine, olanzapine, risperidone, and haloperidol in the treatment of patients with chronic schizophrenia and schizoaffective disorder.

An important parameter in assessing the risk during routine clinical use of the drug might be the ratio of the concentration producing a 50% block at I Kr compared with the concentration required for modulating the receptor targeted for efficacy.

Doctors in the South and Northeast were more likely to take this hardline stance, said study lead author Dr.

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Aripiprazole, an antipsychotic with a novel mechanism of action, and risperidone vs placebo in patients with schizophrenia and schizoaffective disorder.

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World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Schizophrenia, Part 1: Update 2012 on the acute treatment of schizophrenia and the management of treatment resistance.

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The clinical features of elderly dysthymic patients are typically distinct from those of dysthymic disorder in young adults, and the findings suggest that treatments effective for young adult dysthymic patients may not be as useful in elderly dysthymic patients.

In addition, the effects of some of these copy number variants are not restricted to schizophrenia.

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Background: Volume deficits of the hippocampus and its subfields have been found in schizophrenia and bipolar disorder, which share phenomenological and familial overlap.

There is growing concern regarding metabolic issues related to second-generation antipsychotics in older adults.

Methods: Cell cultures were acutely (8 hours) and chronically (72 hours) treated with MK-801 and further submitted to state-of-the art proteomic analyses.

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The effects of clozapine, risperidone, and olanzapine on cognitive function in schizophrenia.

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The goals of treatment of an acute manic or mixed episode are to alleviate symptoms and allow a return to usual levels of psychosocial functioning.

Therefore, it was important to test whether switching to ziprasidone versus switching to some other atypical antipsychotic medication would be beneficial to participants who stopped taking their first antipsychotic medication due to side effects.

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Thus, the spatial arrangement of glutamate synapses, their glutamate transporter buffering zones, and extrasynaptic glutamate receptors will determine the extent and effects of glutamate spillover.

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Results: Cognitively normal range patients were marginally superior to cognitively normal range controls on the Working Memory and marginally inferior on the Processing Speed and Reasoning and Problem Solving MCCB domains.

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To our knowledge, this study is the first time these technologies have been paired together; and the first time they have been applied to a role-play task.

Catatonia as a risk factor for the development of neuroleptic malignant syndrome: report of a case following treatment with clozapine.

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These conditions which are sometimes underdiagnosed in clinical practice must be addressed by appropriate adjunctive psychosocial approaches or other treatments.

Methods: A total of 192 participants with an SMI diagnosis (schizophrenia spectrum, bipolar disorder and major depressive disorder) completed a battery of neurocognitive and psychiatric measures.

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