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We present the mean change scores using an ANCOVA model and rate of change (per week) using a linear mixed-effects model.

Testing HIV positive is a life-changing event, and anxiety around a positive diagnosis is perfectly normal.

Conclusion: There is an association between maternal obesity and psychosis-related outcomes even after adjusting for potential confounders.

Las drogas genéricas son los mismos productos, como los de Brand, pero ellos están producidos y distribuídos sin defensa del patente.

Higher BMI during childhood is associated with an increased risk of coronary heart disease in adulthood ().

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Extended-Release Antipsychotics for the Treatment of Schizophrenia.

The two drugs with the greatest effects on body weight, olanzapine and clozapine, also have high affinity for the 5-HT2C and histamine H1 receptors, which implicate these receptors in antipsychotic-induced weight gain, while peripheral M3 muscarinic receptor antagonism as well as central 5-HT2C effects may contribute to obesity-independent diabetes.

MT-related gene alterations were more prominent in layer 3 pyramidal cells, whereas UPS-related gene alterations were more prominent in layer 5 pyramidal cells.

Schizophrenia is a chronic psychotic disorder, either persistent or episodic, whose hallmark features may include delusions, hallucinations, disturbed thinking processes, flattening of affect, and abnormal behaviors.

Olanzapine alone may be considered for BD depression, but adverse effects require caution.

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Ziprasidone works by changing some of the chemicals in the brain that cause psychotic disorders.

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In this study, we examined the effect of an increase in stop-signal probability on behavioral and event related potential (ERP) measures between patients with schizophrenia, their first degree relatives, and healthy controls.

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Laboratory based decision making was measured using a version of the Balloon Analogue Risk Task (BART).

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Conclusion: This pattern of results highlights the contributions of basic visual signal and spatial integration to impaired face processing in schizophrenia.

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Conclusion: Compared to placebo, PP3M significantly delayed time to first relapse in patients with schizophrenia, previously treated for 4 months with PP1M.

The anxiety, worry, or physical symptoms cause clinically significant distress or impairment in social or occupational functioning.

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Conclusion: Negative symptoms alone account for over half of the FEP patients not achieving full remission after two years of treatment in a specialized early intervention treatment program with amotivation (avolition and anhedonia) as the overwhelming negative symptom.

In this study, we examined interhemispheric interaction in the occipital region by measuring EEG coherence during a visual object recognition task.

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If withdrawal from another agent is suspected, replacement of the agent with another that has similar pharmacologic properties should be attempted if safe and appropriate (eg, nicotine for nicotine withdrawal).

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Both valproate and drug-induced weight gain appear to raise serum insulin levels; the resulting hyperinsulinemia further stimulates ovarian androgen production.

Metformin, a first line treatment in the general population for prediabetes and DM2, has been studied as an adjunctive intervention for AAP-related weight gain.

Click on citations within drug and disease topics in our clinical reference to review the clinical evidence on MEDLINE.

Shaughnessy, PharmD, Tufts University Family Medicine Residency at Cambridge Health Alliance, Malden, Mass.

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Mood disorders encompass a wide array of mood issues, such as major depressive disorder, dysthymic disorder and bipolar disorder.

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Increasing difficulty was expected to result in reduced processing of irrelevant sensory information, which was 40Hz white noise bursts played binaurally during the task, eliciting the N1 auditory evoked potential.

Results: Results showed that schizophrenia patients and their relatives performed worse on maintenance, low-demand manipulation and high-demand manipulation tasks compared to controls and patients with bipolar disorder.

For patients who stop their first medication because of side effects, there is no clear evidence for switching to one atypical medication over another.

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Drink plenty of water to stay hydrated while taking the drug, and never take more than prescribed.

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The aim of this study is to validate this molecular signature (phosphorylation of DISC1 at Serine713) as a biological marker for brain anatomy and function relevant to psychotic disorders, such as schizophrenia (SZ).

Excessive mortality or nonfatal cardiac arrest rate was seen in patients with asymptomatic nonlife-threatening ventricular arrhythmias and myocardial infarction more than six days but less than two years previously who received flecainide compared with patients assigned to a carefully matched placebo in the Cardiac Arrhythmia Suppression Trial (CAST).

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The pathophysiology of bipolar affective disorder, or manic-depressive illness (MDI), has not been determined, and no objective biologic markers correspond definitively with the disease state.

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